Bacterial Signal Transduction
Our lab has a long-standing interest in stress response and transmembrane signal transduction in the enterobacterium Escherichia coli, the marine bacterium Vibrio harveyi, and the entomopathogen Photorhabdus luminescens. Our work is focused on the structural and functional analysis of membrane-integrated receptors and secondary transporters. Moreover, we aim to understand the regulatory network of bacterial cells by using combined experimental and systems biological approaches. Recently, we started to analyze stress dependent gene expression at single cell level within a population. We quantify cooperativity and individuality within bacterial populations in the context of metabolism-based chemical communication under various external conditions.